解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Intraoperative fluorescence imaging is particularly well-suited for surgical applications due to its inherently high sensitivity, resolution, and ability to provide images in real-time. To date, the intraoperative observation of fluorescence has largely been subjective. With the need to show objective evidence in orde...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.27384
更新日期:2018-10-22 00:00:00
abstract::In ultrasound molecular imaging (USMI), ligand-functionalized microbubbles (MBs) are used to visualize vascular endothelial targets. Netrin-1 is upregulated in 60% of metastatic breast cancers and promotes tumor progression. A novel netrin-1 interference therapy requires the assessment of netrin-1 expression prior to ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.27221
更新日期:2018-10-06 00:00:00
abstract::In advanced atherosclerotic plaques, defective efferocytosis of apoptotic foam cells and decreased cholesterol efflux contribute to lesion progression. In our previous study, we demonstrated that 5-aminolevulinic acid (ALA)-mediated sonodynamic therapy (SDT) could induce foam cells apoptosis via the mitochondrial-casp...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.26193
更新日期:2018-09-29 00:00:00
abstract::Reperfusion as a therapeutic intervention for acute myocardial infarction-induced cardiac injury itself induces further cardiomyocyte death. β-arrestin (βarr)-biased β-adrenergic receptor (βAR) activation promotes survival signaling responses in vitro; thus, we hypothesize that this pathway can mitigate cardiomyocyte ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.26619
更新日期:2018-09-09 00:00:00
abstract::Traumatic brain injury (TBI) research has focused on moderate to severe injuries as their outcomes are significantly worse than those of a mild TBI (mTBI). However, recent epidemiological evidence has indicated that a series of even mild TBIs greatly increases the risk of neurodegenerative and psychiatric disorders. N...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.24747
更新日期:2018-09-09 00:00:00
abstract::Proper selection and effective delivery of combination drugs targeting multiple pathophysiological pathways key to spinal cord injury (SCI) hold promise to address the thus far scarce clinical therapeutics for improving recovery after SCI. In this study, we aim to develop a clinically feasible way for targeted deliver...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.26717
更新日期:2018-08-07 00:00:00
abstract::Cancer vaccines have encountered their ideal personalized partner along with evidence for great breakthroughs in the identification and synthesis of neoantigens. Individual cancer neoantigen vaccines are capable of eliciting robust T-cell responses and have been demonstrated to achieve striking clinical efficacy due t...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.24387
更新日期:2018-07-30 00:00:00
abstract::Despite significant advances in cancer diagnostics and treatment, ovarian cancers (OC) continue to kill more than 150,000 women every year worldwide. Due to the relatively asymptomatic nature and the advanced stage of the disease at the time of diagnosis, OC is the most lethal gynecologic malignancy. The current treat...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.26345
更新日期:2018-07-30 00:00:00
abstract::Near-infrared (NIR) fluorescence imaging has relied on fluorophores that emit in the 700-900 nm NIR-Ia or 1,000-1,700 nm NIR-II window for generating deep-tissue images. Up until now, there have been few fluorophores developed for the 900-1,000 nm NIR-Ib window. This is largely because NIR-Ib light is thought to be st...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.26539
更新日期:2018-07-16 00:00:00
abstract::Sodium/iodide symporter (NIS)-mediated iodide uptake in thyroid follicular cells is the basis of clinical utilization of radioiodines. The cloning of the NIS gene enabled applications of NIS as a reporter gene in both preclinical and translational research. Non-invasive NIS imaging with radioactive iodides and iodide ...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.24997
更新日期:2018-06-24 00:00:00
abstract::Rationale: Saliva as a sample matrix is rapidly gaining interest for disease diagnosis and point-of-care assays because it is easy to collect (non-invasive) and contains many health-related biomarkers. However, saliva poses particular problems relative to more common urine and blood matrices, which includes low analyt...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.24941
更新日期:2018-06-13 00:00:00
abstract::Both adjuvants and focal ablation can alter the local innate immune system and trigger a highly effective systemic response. Our goal is to determine the impact of these treatments on directly treated and distant disease and the mechanisms for the enhanced response obtained by combinatorial treatments. Methods: We com...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.25613
更新日期:2018-06-07 00:00:00
abstract::Protein therapeutics is playing an increasingly critical role in treatment of human diseases. However, current vectors are captured by the digestive endo-lysosomal system, which results in an extremely low fraction (<2%) of protein being released in the cytoplasm. This paper reports a drug-delivering-drug platform (HA...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.23804
更新日期:2018-06-06 00:00:00
abstract::Rationale: The ability to treat invalidating neurological diseases is impeded by the presence of the blood-brain barrier (BBB), which inhibits the transport of most blood-borne substances into the brain parenchyma. Targeting the transferrin receptor (TfR) on the surface of brain capillaries has been a popular strategy...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.25228
更新日期:2018-05-24 00:00:00
abstract::In the past decade, iron oxide nanoparticles (IONPs) have attracted more and more attention for their excellent physicochemical properties and promising biomedical applications. In this review, we summarize and highlight recent progress in the design, synthesis, biocompatibility evaluation and magnetic theranostic app...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.25220
更新日期:2018-05-11 00:00:00
abstract::Rationale: Increasing frequency of human exposure to PEG-related products means that healthy people are likely to have pre-existing anti-PEG antibodies (pre-αPEG Ab). However, the influence of pre-αPEG Abs on the pharmacokinetics (PK) and therapeutic efficacy of LipoDox is unknown. Methods: We generated two pre-αPEG A...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.22164
更新日期:2018-05-09 00:00:00
abstract::Rationale: Colitis-associated colorectal cancer (CAC) usually exhibits an accelerated disease progression, an increased resistance to therapeutic drugs and a higher mortality rate than sporadic colorectal cancer (CRC). PIAS3 is a member of the protein inhibitor of activated STAT (PIAS) family; however, little is known...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.23046
更新日期:2018-04-30 00:00:00
abstract::Histone deacetylase 3 (HDAC3) plays a pivotal role in the repression of cartilage-specific gene expression in human chondrocytes. The aim of this study was to determine whether microRNA-193b-3p (miR-193b-3p) regulates the expression of HDAC3 during chondrogenesis and chondrocyte metabolism. Methods: miR-193b-3p expres...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.23547
更新日期:2018-04-15 00:00:00
abstract::Extracellular vesicles (EVs), or exosomes, are nanovesicles of endocytic origin that carry host and pathogen-derived protein, nucleic acid, and lipid cargos. They are secreted by most cell types and play important roles in normal cell-to-cell communications but can also spread pathogen- and host-derived molecules duri...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.20576
更新日期:2018-04-09 00:00:00
abstract::Rationale: Treating diseases of the brain such as Alzheimer's disease (AD) is challenging as the blood-brain barrier (BBB) effectively restricts access of a large number of potentially useful drugs. A potential solution to this problem is presented by therapeutic ultrasound, a novel treatment modality that can achieve...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.22852
更新日期:2018-04-03 00:00:00
abstract::Recently, researchers identified a distinct vessel subtype called type H vessels that couple angiogenesis and osteogenesis. We previously found that type H vessels are reduced in ovariectomy (OVX)-induced osteoporotic mice, and preosteoclasts are able to secrete platelet-derived growth factor-BB (PDGF-BB) to stimulate...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.22144
更新日期:2018-03-28 00:00:00
abstract::Development of a rapid and sensitive method for Aβ(1-42) aggregation detection is of great importance to overcome the limitations of conventional techniques. In this study, we developed a label-free paper-based electrochemiluminescence sensor for amyloid-β aggregation detection toward potential diagnosis of Alzheimer'...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.23483
更新日期:2018-03-11 00:00:00
abstract::Intraoperative imaging with antibodies labeled with both a radionuclide for initial guidance and a near-infrared dye for adequate tumor delineation may overcome the main limitation of fluorescence imaging: the limited penetration depth of light in biological tissue. In this study, we demonstrate the feasibility and sa...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.23335
更新日期:2018-03-08 00:00:00
abstract::Folate receptor (FR) has proven to be a valuable target for chemotherapy using folic acid (FA) conjugates. However, FA-conjugated chemotherapeutics still have low therapeutic efficacy accompanied with side effects, resulting from complications such as short circulation half-life, limited tumor delivery, as well as hig...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.24382
更新日期:2018-02-16 00:00:00
abstract::Purpose: Systemic administration of free chemotherapeutic drugs leads to severe toxic effects, and physiological characteristics of solid tumors restrain the drugs from reaching the hypoxic regions. E. coli Nissle 1917 (EcN) has been known to penetrate the barrier and proliferate in the interface between the viable an...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.21575
更新日期:2018-02-12 00:00:00
abstract::Over 70% of head & neck squamous cell carcinoma (HNSCC) patients carry TP53 oncogenic mutations. Here we studied the role of specific tumor-derived mutant p53 proteins in the aberrant transcription of long non-coding (lnc) MIR205HG gene in head and neck cancer cells. Methods: To understand the role of lncMIR205HG, tha...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.22167
更新日期:2018-02-12 00:00:00
abstract::Exosomes play critical roles in intercellular communication in both nearby and distant cells in individuals and organs. Polymerase I and transcript release factor (PTRF), also known as Cavin1, has previously been described as a critical factor in caveola formation, and aberrant PTRF expression has been reported in var...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.22952
更新日期:2018-02-07 00:00:00
abstract::Rationale: Among the biothiols-related diseases, sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection and can result in severe oxidative stress and damage to multiple organs. In this study, we aimed to develop a fluorescence chemosensor that can both detect GSH an...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.22252
更新日期:2018-02-03 00:00:00
abstract::Rationale: Mxi1 is regarded as a potential tumor suppressor protein that antagonizes the transcriptional activity of proto-oncogene Myc. However, the clinical significances and underlying mechanisms by which Mxi1 is regulated in lung cancer remain poorly understood. Methods: Mass spectrometry analysis and immunoprecip...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.22552
更新日期:2018-02-02 00:00:00
abstract::Osteoarthritis (OA) is a rheumatic disease leading to chronic pain and disability with no effective treatment available. Recently, allogeneic human mesenchymal stromal/stem cells (MSC) entered clinical trials as a novel therapy for OA. Increasing evidence suggests that therapeutic efficacy of MSC depends on paracrine ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.20746
更新日期:2018-01-01 00:00:00
abstract::Comprehensive analysis of the expression level and location of tumor-associated membrane proteins (TMPs) is of vital importance for the profiling of tumor cells. Currently, two kinds of independent techniques, i.e. ex situ detection and in situ imaging, are usually required for the quantification and localization of T...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.22794
更新日期:2018-01-01 00:00:00
abstract::In pancreatic cancer (PDAC) intratumor infiltration of polymorphonuclear neutrophils (PMN) is associated with histologically apparent alterations of the tumor growth pattern. The aim of this study was to examine possible associations between PMN infiltration, tumor microarchitecture, and water diffusivity in diffusion...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.21089
更新日期:2018-01-01 00:00:00
abstract::The application of blood plasma for soft tissue wound healing is receiving much more attention recently. Exosomes are critical paracrine mediators that can be obtained from biological fluids including plasma and be able to induce regenerative effects by transferring bioactive molecules such as microRNAs (miRNAs). This...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.21234
更新日期:2018-01-01 00:00:00
abstract::High-dose radiotherapy effects are regulated by acute tumour endothelial cell death followed by rapid tumour cell death instead of canonical DNA break damage. Pre-treatment with ultrasound-stimulated microbubbles (USMB) has enabled higher-dose radiation effects with conventional radiation doses. This study aimed to co...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.19010
更新日期:2018-01-01 00:00:00
abstract::Topical administration permits targeted, sustained delivery of therapeutics to human skin. Delivery to the skin, however, is typically limited to lipophilic molecules with molecular weight of < 500 Da, capable of crossing the stratum corneum. Nevertheless, there are indications protein delivery may be possible in barr...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.21668
更新日期:2018-01-01 00:00:00
abstract::INTRODUCTION: According to the "glymphatic system" hypothesis, brain waste clearance is mediated by a continuous replacement of the interstitial milieu by a bulk flow of cerebrospinal fluid (CSF). Previous reports suggested that this cerebral CSF circulation is only active during general anesthesia or sleep, an effect...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.19154
更新日期:2018-01-01 00:00:00
abstract::Background: Tumor cells require proficient autophagy to meet high metabolic demands and resist chemotherapy, which suggests that reducing autophagic flux might be an attractive route for cancer therapy. However, this theory in clinical cancer research remains controversial due to the limited number of drugs that speci...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.22012
更新日期:2018-01-01 00:00:00
abstract::This article aims at alerting scientists working with nanoparticles or microparticles about the specific adverse reactions due to the intravascular pulmonary macrophages present in pigs and other cloven-hoof animals, but not in humans. The history of a 25-year old study of an ultrasound contrast agent is used to illus...
journal_title:Theranostics
pub_type: 评论,杂志文章
doi:10.7150/thno.22420
更新日期:2017-10-23 00:00:00
abstract::Rationale: Dimethyl sulfoxide (DMSO) is commonly used as a solvent for water-insoluble substances, a vehicle for drug therapy, and a cryoprotectant for cultured cells. DMSO induced embryonic defects and its mechanism of action remains unclear. The rationale is based on the assumption that DMSO supplementation should i...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.21662
更新日期:2017-10-17 00:00:00
abstract::Rationale: Signal transducer and activator of transcription-3 (STAT3) plays a pivotal role in cancer biology. Many small-molecule inhibitors that target STAT3 have been developed as potential anticancer drugs. While designing small-molecule inhibitors that target the SH2 domain of STAT3 remains the leading focus for d...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.18630
更新日期:2017-10-16 00:00:00